Please use this identifier to cite or link to this item:
http://studentrepo.iium.edu.my/handle/123456789/5918
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alfatama, Mulham | en_US |
dc.date.accessioned | 2020-08-20T12:18:48Z | - |
dc.date.available | 2020-08-20T12:18:48Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://studentrepo.iium.edu.my/jspui/handle/123456789/5918 | - |
dc.description.abstract | Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata using known extraction procedure, and to find optimum condition for microencapsulation by employing double emulsion solvent evaporation method. Biodegradable poly (D, L-lactide-co-glycolide) (PLGA) was the polymer of interest to encapsulate the C. alata extracts owing to its ability to give a controlled-release profile. Resultant microspheres were characterized for size distribution and external morphology by laser diffraction technique and scanning electron microscopy, respectively. Encapsulation efficiency (EE) was also calculated and the C. alata was quantified by UV absorbance. Several parameters have been investigated to optimize the characteristic of fabricated microspheres during the preparation process including different homogenization times for the primary emulsion, different volume ratios of aqueous/oil phases, several types and concentrations of surfactants, co-solvent in aqueous or oil phase and buffer systems (at varying pH and different concentrations of PBS). It was found that, most of the parameters employed resulted in low EE (<11%), however the encapsulation efficiency (64%) was significantly improved when the hardening tank is buffered to pH 7, with minimal effect on particle size. The particle size range obtained was between 6-30 ?m. Subsequent in vitro analysis displayed usual release pattern attributed to PLGA that is initial burst release followed by a gradual release phase up to the period of study. Although our C. alata extract did not show antimicrobial and antifungal activities against various strains tested but it appeared active against Escherichia coli. It is hereby suggested that our C. alata microspheres may be useful as preservative and antidote related to food-poisoning commonly caused by Escherichia coli. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Kuala Lumpur : International Islamic University Malaysia, 2013 | en_US |
dc.rights | Copyright International Islamic University Malaysia | |
dc.subject.lcsh | Microspheres (Pharmacy) | en_US |
dc.subject.lcsh | Legumes | en_US |
dc.subject.lcsh | Medicinal plants | en_US |
dc.title | Development of microspheres containing Cassia alata extract | en_US |
dc.type | Master Thesis | en_US |
dc.identifier.url | https://lib.iium.edu.my/mom/services/mom/document/getFile/sY4666S3TPGVqR7UmwgkXCoHrq9oc1ow20130927163709399 | - |
dc.description.identity | t00011285315Mulham | en_US |
dc.description.identifier | Thesis : Development of microspheres containing Cassia alata extract /by Mulham Alfatama | en_US |
dc.description.kulliyah | Kulliyyah of Pharmacy | en_US |
dc.description.programme | Master in Pharmaceutical Science (Pharmacceutical Technology) | en_US |
dc.description.degreelevel | Master | en_US |
dc.description.callnumber | t RS 201 M53 A385D 2013 | en_US |
dc.description.notes | Thesis (MSPHT)--International Islamic University Malaysia, 2013 | en_US |
dc.description.physicaldescription | xvii, 133 leaves : ill. ; 30cm. | en_US |
item.openairetype | Master Thesis | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | KOP Thesis |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
t00011285315Mulham_SEC_24.pdf | 24 pages file | 498.53 kB | Adobe PDF | View/Open |
t00011285315Mulham_SEC.pdf Restricted Access | Full text secured file | 2.31 MB | Adobe PDF | View/Open Request a copy |
Page view(s)
24
checked on May 18, 2021
Download(s)
8
checked on May 18, 2021
Google ScholarTM
Check
Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated. Please give due acknowledgement and credits to the original authors and IIUM where applicable. No items shall be used for commercialization purposes except with written consent from the author.